Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies

Cardiometabolic disorders are among the leading causes of mortality in human population. Dietary polyphenols exert beneficial effects on cardiometabolic health humans. Molecular mechanisms, however, not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses elucidate molecular mechanisms underlying protective health, we first conducted a systematic literature search identify intervention studies with that demonstrate improvement risk factors parallel significant nutrigenomic effects. Applying predefined inclusion criteria, identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed peripheral blood cells RT-PCR methods. Subsequent demonstrated modulate mainly involved processes such as inflammation, lipid metabolism, endothelial function. We also 37 transcription regulation polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative analysis miRNA-target pathways several common enriched include MAPK signaling pathway, TNF PI3K-Akt focal adhesion, PPAR pathway. These represent valuable source information for identification potential target future nutrigenetic studies.